2008 BTS Research Grants
Kenneth Aldape, MD
Role of YKL-40-beta-catenin signaling axis in GBM progression and radio-resistance
The University of Texas
MD Anderson Cancer Center
Houston, Texas
Matched to James F. Petersen Chair of Research
(Also see Dr. Kenneth Aldape's Oligodendroglioma research with funding from NBTF's Basic/Translational Grant Award)
Azad Bonni, MD, PhD
Regulation of glioblastoma pathogenesis by EGFRvIII – STAT3 signaling
Harvard Medical School
Boston, Massachusetts
Matched to Sam Gerson Chair of Research
Nadia Dahmane, PhD
Mechanisms regulating stem cell behavior in glioma
Wistar Institute
Philadelphia, Pennsylvania
Matched to James F. Petersen Chair of Research
Arti Gaur, PhD
Role of mir-10a and mir-10b in regulating the pathology of glioblastoma multiforme
Dartmouth College Medical School
Lebanon, New Hampshire
Matched to Paul Daniel Bogart Chair of Research
Samira Guccione, PhD
Anti-angiogenic targeted-nanoparticle therapy in canine spontaneous brain tumors
Stanford University
Stanford, California
Matched to James F. Petersen Chair of Research
Amy B. Heimberger, MD
Targeting gliomas with a novel inhibitor of the JAK2/STAT3 pathway
The University of Texas
MD Anderson Cancer Center
Houston, Texas
Matched to Kayla Wenger Chair of Research
Lawrence Lamb, PhD
Feasibility of T cell immunotherapy for glioblastoma multiforme
University of Alabama at Birmingham
Birmingham, Alabama
Matched to Sam Gerson Chair of Research
Duane Mitchell, MD, PhD
Clinical development of dendritic cell vaccines targeting brain tumor stem cells
Duke University Medical Center
Durham, North Carolina
Matched to Billy Grey Chair of Research
John Sampson, MD, PhD
Inhibition of regulatory T cell recovery with an IL-2 receptor blocking antibody
Duke University Medical Center
Durham, North Carolina
Matched to Patty Roche Chair of Research
Axel H. Schonthal, PhD
Blocking autophagy and increasing ER stress to improve therapy of GBM
University of Southern California
Los Angeles, California
Matched to Mickey McDonald Welker Chair of Research
Robert Sobol, PhD
PARG regulation of temozolomide induced mitotic checkpoint activation
University of Pittsburgh
Pittsburgh, Pennsylvania
Matched to Seth Harris Feldman Chair of Research
Paul Watkins, MD, PhD
ACSVL3-A novel therapeutic target in malignant glioma
Kennedy Krieger Institute
Baltimore, Maryland
Matched to Sydney Schlobohm Chair of Research
William Weiss, MD, PhD
Inhibition of P13K and Cdks in glioma
University of California, San Francisco
San Francisco, California
Matched to Benjamin Memmott Chair of Research
Hai Yan, MD, PhD
The role of HDMX in GBM oncogenesis and chemoresistance
Duke University
Durham, North Carolina
Matched to Eliza Lorberbaum Chair of Research
Joseph Costello, PhD
Evolution of a hypomethylator phenotype in glioblastoma
University of California, San Francisco
San Francisco, California
Tom Curran, PhD, FRS
Generation and characterization of conditional cancer mouse models for atypical teratoic/rhabdoid tumor and choroid plexus carcinoma
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
Juan Fueyo, MD
Oncolytic adenoviruses against brain tumor stem cells: The role of autophagy
The University of Texas M.D. Anderson Cancer Center
Houston, Texas
Abhijit Guha, MD, FRCSC, FACS
Regional expression and functional role of inhibitors of apoptosis in human GBM
University of Toronto
Toronto, Ontario
Anita B. Hjelmeland, PhD
Targeting radiation resistance in brain tumor stem cells
Duke University
Durham, North Carolina
Eric C. Holland, MD, PhD
Investigating the role of DNA damage response in gliomagenesis and "cancer stem cell" resistance to irradiation
Memorial Sloan Kettering Cancer Center
New York, New York
Annie Huang, MD, PhD
Characterization of cell adhesion pathways in childhood sPNET
Hospital For Sick Children
Toronto, Ontario
Charles Keller, MD
Proteasome inhibitor mediated reversal of Shh-driven tumorigenesis
University of Texas Health Science Center at San Antonio
San Antonio, Texas
Paul Knoepfler, PhD
Functional genomics analysis of primitive neuroectodermal tumors
University of California, Davis
Davis, California
Qing Richard Lu, PhD
Mitotic olig2 expressing cells in glioma formation
University of Texas Southwestern Medical Center
Dallas, Texas
Zhimin Lu, MD, PhD
Investigation of the mechanism underlying chemoresistance of glioblastoma multiforme to platinum treatment
The University of Texas M.D. Anderson Cancer Center
Houston, Texas
Sadhan Majumder, PhD
Novel mechanism of glioblastoma tumorgenesis and therapy
The University of Texas M.D. Anderson Cancer Center
Houston, Texas
Jeremy Rich, MD
Glioma cancer stem cells in tumor angiogenesis
Duke University Medical Center
Durham, North Carolina
Joshua Rubin, MD, PhD
Defining the basis of enhanced CXCR4 signaling in brain tumors
Washington University
St. Louis, Missouri
2007 BTS Research Grants
Anne Brunet, PhD
Defining the role of Foxo transcription factors and Sirt1 deacetylase in suppressing glioblastoma
Stanford University
Stanford, California
James Chen, MD
Novel Hedgehog pathway antagonists as potential medulloblastoma therapeutics
Stanford University
Stanford, California
Joseph Costello, PhD
Evolution of a hypomethylator phenotype in glioblastoma
University of California, San Francisco
San Francisco, California
Tom Curran, PhD, FRS
Generation and characterization of conditional cancer mouse models for atypical teratoid/rhabdoid tumor and choid plexus carcinoma
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
Juan Fueyo, MD
Oncolytic adenoviruses against brain tumor stem cells: the role of autophagy
The University of Texas M.D. Anderson Cancer Center
Houston, Texas
Richard Gilbertson, MD, PhD
The role of Notch cell signaling and INK4A/ARF deletion in the transformation of radial glia to ependymoma cancer stem cells
St. Jude Children's Research Hospital
Memphis, Tennessee
Abhijit Guha, MD, FRCSC, FACS
Regional expression and functional role of inhibitors of apoptosis in human GBM
University of Toronto
Toronto, Ontario
Gregory Hannon, PhD
Genetic approaches to new therapeutic targets in brain cancer
Cold Spring Harbor Laboratory
Cold Spring Harbor, New York
Xiaolin He, PhD
Structural mechanisms of receptor signaling in brain tumor angiogenesis
Northwestern University
Chicago, Illinois
Rakesh Jain, PhD
Targeting stromal and tumor compartments in glioblastomas
Massachusetts General Hospital
Boston, Massachusetts
Paul Knoepfler, PhD
Functional genomics analysis of primitive neuroectodermal tumors
University of California, Davis
Davis, California
Lawrence Lamb, PhD
Feasibility of γδ T cell immunotherapy for glioblastoma multiforme
University of Alabama at Birmingham
Birmingham, Alabama
Zhimin Lu, MD, PhD
Investigation of the mechanisms underlying chemoresistance of glioblastoma multiforme to platinum treatment
The University of Texas M.D. Anderson Cancer Center
Houston, Texas
Duane Mitchell, MD, PhD
Clinical development of dendritic cell vaccines targeting brain tumor stem cells
Duke University Medical Center
Durham, North Carolina
Jeremy Rich, MD
Glioma cancer stem cells in tumor angiogenesis
Duke University Medical Center
Durham, North Carolina
Joshua Rubin, MD, PhD
Defining the basis of enhanced CXCR4 signaling in brain tumors
Washington University
St. Louis, Missouri
John Sampson, MD, PhD
Inhibition of regulatory T cell recovery with an IL-2 receptor blocking antibody
Duke University Medical Center
Durham, North Carolina
Robert Sobol, PhD
PARG regulation of temozolomide induced mitotic checkpoint activation
Universtiy of Pittsburgh
Pittsburgh, Pennsylvania
Special Projects: Low-Grade Glioma (LGG) Initiative
Jeffrey Leonard, MD
Controlling pilocytic astrocyoma growth: Effects of location, age, and telomerase
Washington University
St. Louis, Missouri
Ian Pollack, MD
Molecular prognostic markers for low-grade gliomas
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania
Uri Tabori, MD
The biologic and prognostic role of replicative and oncogene induced senescence in pediatric low-grade gliomas
University of Toronto, The Hospital For Sick Children
Toronto, Ontario
Kwong Kwok Wong, PhD
Development of permanent juvenile pilocytic astrocyoma cell lines for preclinical trials
The University of Texas M.D. Anderson Cancer Center
Houston, Texas
David Gutmann, MD, PhD
Washington University
St. Louis, Missouri
and
Tobey Macdonald, MD
Children's National Medical Center
Washington, DC
A joint investigation of
Identification of key genetic and growth control pathway changes in pediatric fibrillary astrocytomas (PFA) that represent potential molecular targets for therapeutic intervention
