Cancer research, particularly in brain tumors, has reached a point requiring change in approaches to identify new effective therapies. The complexity of cancer discovery calls for integration of traditionally separate disciplines including biology genomics, chemistry, mathematics, computer science, engineering, and physics. The field of integrated cancer research, including systems biology, has emerged and is now ready to advance the search for new therapies in bold new ways.
National Brain Tumor Society recently held the research symposium, Stepping Up To The Complexity Challenge: The Systems Biology Era of Cancer Research. The symposium invited systems biology experts from the National Cancer Institute’s Integrative Cancer Biology Program (ICBP), as well as science, government, and patient advocacy leaders to share their vision for future systems biology approaches to cancer research and identify opportunities to advance the field.
Videos and transcripts of the presentations are posted below to give the cancer community an opportunity to revisit the symposium’s topics and continue the discussion in this exciting and still emerging era of cancer research. We ask that you comment, share opinions, and present questions on the NBTS Scientific Insights discussion board.
Panel Discussion
Introductions:
David F. Arons, JD: Director of Public Policy, National Brain Tumor Society
Facilitator:
Michael E. Berens, PhD: Professor and Director, Cancer and Cell Biology Division, TGen
Panelists:
Daniel Gallahan, PhD: Deputy Director, Division of Cancer Biology, NCI; Program Director, ICBP
Vito Quaranta, MD: Director, Center for Cancer Systems Biology, Vanderbilt University
N. Paul TonThat: Executive Director, National Brain Tumor Society
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Introduction
Daniel Gallahan, PhD: Deputy Director, Division of Cancer Biology, NCI Program Director, ICBPn
Why We Need Brain Tumor and Cancer Systems Biology Research
Michael B. Yaffe, MD, PhD: Professor, Biology and Biological Engineering, Koch Institute for Integrative Cancer
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Translating Cancer Genomics
Lynda Chin, MD: Professor and Chair, Department of Genomic Medicine, MD Anderson Cancer Center March 2012
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Interrogating High-Grade Glioma Regulatory Networks to Identify Master Regulators of Tumor Subtype and Associated Driver Mutations
Andrea Califano, PhD: Founding Director, Columbia Initiative in Systems
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Relating the Genetic Features of Human Cancers to Drug Efficiencies Comprehensively
Stuart L. Schreiber, PhD: Director of Chemical Biology, Broad Institute of Harvard and MIT
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Mathematical Modeling of Brain Tumor Biology
Thomas S. Deisboeck, MD: Director, Complex Biosystems Modeling Laboratory, Harvard – MIT Athinoula A. Marinos Center for Biomedical Imaging
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Q&A Session
Presenters field questions from the audience and share additional insights into the growing field of systems biology and it's applicability to developing new therapies for brain tumor patients.
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